Brion Mélanie, Pitel Anne-Lise, D'Hondt Fabien
Laboratory for Experimental Psychopathology, Psychological Sciences Research Institute, Université catholique de Louvain Louvain-la-Neuve, Belgium.
INSERM, Unité U1077, École Pratique des Hautes Études, Université de Caen-Basse Normandie - GIP Cyceron - CHU Caen Caen, France.
Front Psychol. 2016 Feb 16;7:168. doi: 10.3389/fpsyg.2016.00168. eCollection 2016.
This perspective aims at underlining the usefulness of event-related potentials (ERP) to better understand the brain correlates of Korsakoff's syndrome (KS), a neuropsychiatric disease characterized by severe memory impairment and most frequently resulting as a neurological complication of alcohol-dependence (AD). While ERP have been broadly used in AD, it has up to now been very little applied in KS or in the comparison of KS and AD. Within the framework of dual-process models, an influential theory postulating that addictive states result from an imbalance between under-activated reflective system and over-activated automatic-affective one, this paper proposes: (1) a brief synthesis of the main results of ERP studies in AD and KS, and (2) new research avenues using ERP to identify the electrophysiological correlates of cognitive and emotional dysfunction in KS. These experimental perspectives aim at exploring the continuity hypothesis, which postulates a gradient of impairments from AD to KS. We conclude on the possibility of developing neuropsychological strategies with electrophysiological follow-up to ensure KS diagnosis and test the efficacy of patient's neurocognitive rehabilitation.
本观点旨在强调事件相关电位（ERP）对于更好地理解科萨科夫综合征（KS）的大脑关联的有用性。KS是一种神经精神疾病，其特征为严重的记忆障碍，且最常作为酒精依赖（AD）的神经系统并发症出现。虽然ERP已广泛应用于AD研究，但迄今为止在KS中或在KS与AD的比较中应用极少。在双过程模型的框架内，一种有影响力的理论假定成瘾状态是由未充分激活的反思系统和过度激活的自动情感系统之间的失衡导致的，本文提出：（1）对AD和KS中ERP研究的主要结果进行简要综述，以及（2）利用ERP来识别KS中认知和情感功能障碍的电生理关联的新研究途径。这些实验观点旨在探索连续性假说，该假说假定从AD到KS存在损伤梯度。我们得出结论，认为有可能制定具有电生理随访的神经心理学策略，以确保KS的诊断并测试患者神经认知康复的疗效。
