Zheng Yu, Zhou Hong, Dunstan Colin R, Sutherland Robert L, Seibel Markus J
Bone Research Program, ANZAC Research Institute, University of Sydney, NSW 2139, Australia; The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
Bone Research Program, ANZAC Research Institute, University of Sydney, NSW 2139, Australia.
J Bone Oncol. 2012 Dec 11;2(1):47-57. doi: 10.1016/j.jbo.2012.11.002. eCollection 2013 Feb.
The bone microenvironment provides a fertile soil for cancer cells. It is therefore not surprising that the skeleton is a frequent site of cancer metastasis. It is believed that reciprocal interactions between tumour and bone cells, known as the "vicious cycle of bone metastasis" support the establishment and orchestrate the expansion of malignant cancers in bone. While the full range of molecular mechanisms of cancer metastasis to bone remain to be elucidated, recent research has deepened our understanding of the cell-mediated processes that may be involved in cancer cell survival and growth in bone. This review aims to address the importance of the bone microenvironment in skeletal cancer metastasis and discusses potential therapeutic implications of novel insights.
骨微环境为癌细胞提供了肥沃的土壤。因此，骨骼成为癌症转移的常见部位也就不足为奇了。据信，肿瘤细胞与骨细胞之间的相互作用，即所谓的“骨转移恶性循环”，支持了恶性肿瘤在骨中的形成并协调其扩展。虽然癌症转移至骨的全部分子机制仍有待阐明，但最近的研究加深了我们对可能参与癌细胞在骨中存活和生长的细胞介导过程的理解。本综述旨在阐述骨微环境在骨骼癌症转移中的重要性，并讨论新见解的潜在治疗意义。
