Kuchuk Iryna, Beaumont Jennifer L, Clemons Mark, Amir Eitan, Addison Christina L, Cella David
Division of Medical Oncology, Ottawa Regional Cancer Centre and University of Ottawa, Ottawa, Canada.
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, USA.
J Bone Oncol. 2013 Aug 8;2(4):154-7. doi: 10.1016/j.jbo.2013.07.004. eCollection 2013 Dec.
The Brief Pain Inventory (BPI) and Functional Assessment of Cancer Therapy-Bone Pain (FACT-BP) are commonly used measures of patient reported pain outcomes. We report on the performance of the FACT-BP in comparison to the BPI within a small, randomized trial.
Patients with biochemically defined low risk bone metastases were randomized to 4 weekly (control arm) or 12 weekly (de-escalating arm) pamidronate for 1 year. FACT-BP, BPI and serum markers of bone turnover were recorded at baseline and weeks 12, 24, 36 and 48. Mixed effects models were used to compare scores over time between arms. Correlation coefficients were calculated to evaluate the association between FACT-BP and BPI scores, as well as with markers of bone turnover.
Nineteen patients were randomized to each study arm. Pain scores determined by the two instruments were moderately to highly correlated with each other. Baseline C-telopeptide (CTx) level was correlated with baseline FACT-BP and BPI scores. Baseline bone-specific alkaline phosphatase showed a non-significant association with pain scores. There were no correlations between the markers of bone turnover and pain scores at week 12.
In the current study the FACT-BP and BPI correlated well with each other, and with baseline CTx. The possibility of linking subjective pain scores with objective biomarkers of response requires more investigation.
简明疼痛问卷（BPI）和癌症治疗功能评估-骨痛量表（FACT-BP）是常用的患者报告疼痛结局的测量工具。我们在一项小型随机试验中报告了FACT-BP与BPI相比较的表现。
生化定义为低风险骨转移的患者被随机分为接受每周4次（对照组）或每周12次（递减组）帕米膦酸治疗1年。在基线以及第12、24、36和48周记录FACT-BP、BPI和骨转换血清标志物。使用混合效应模型比较两组随时间的得分。计算相关系数以评估FACT-BP与BPI得分之间的关联，以及与骨转换标志物的关联。
每个研究组随机分配了19名患者。两种工具测定的疼痛得分彼此中度至高度相关。基线C-末端肽（CTx）水平与基线FACT-BP和BPI得分相关。基线骨特异性碱性磷酸酶与疼痛得分的关联不显著。在第12周时，骨转换标志物与疼痛得分之间无相关性。
在当前研究中，FACT-BP和BPI彼此相关性良好，且与基线CTx相关。将主观疼痛得分与客观反应生物标志物联系起来的可能性需要更多研究。
