Rosario Pedro Weslley, Mourão Gabriela Franco
Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
Arch Endocrinol Metab. 2016 Feb;60(1):5-8. doi: 10.1590/2359-3997000000158.
This prospective study evaluated the recurrence rate in low-risk patients with papillary thyroid cancer (PTC) who presented slightly elevated thyroglobulin (Tg) after thyroidectomy and who did not undergo ablation with131I.
The study included 53 low-risk patients (nonaggressive histology; pT1b-3, cN0pNx, M0) with slightly elevated Tg after thyroidectomy (> 1 ng/mL, but ≤ 5 ng/mL after levothyroxine withdrawal or ≤ 2 ng/mL after recombinant human TSH).
The time of follow-up ranged from 36 to 96 months. Lymph node metastases were detected in only one patient (1.9%). Fifty-two patients continued to present negative neck ultrasound. None of these patients without apparent disease presented an increase in Tg.
Low-risk patients with PTC who present slightly elevated Tg after thyroidectomy do not require ablation with 131I.
本前瞻性研究评估了甲状腺乳头状癌（PTC）低风险患者在甲状腺切除术后甲状腺球蛋白（Tg）轻度升高且未接受131I消融治疗时的复发率。
该研究纳入了53例低风险患者（组织学无侵袭性；pT1b - 3，cN0pNx，M0），这些患者在甲状腺切除术后Tg轻度升高（>1 ng/mL，但在停用左甲状腺素后≤5 ng/mL或在重组人促甲状腺素刺激后≤2 ng/mL）。
随访时间为36至96个月。仅1例患者（1.9%）检测到淋巴结转移。52例患者颈部超声检查持续为阴性。这些无明显疾病的患者中，Tg均未升高。
甲状腺切除术后Tg轻度升高的PTC低风险患者无需接受131I消融治疗。
