醛腙的氧化C(sp(2))-H膦酰化反应
Oxidative C(sp(2))-H Phosphonation of Aldehyde Hydrazones.
作者信息
Xu Pan, Wu Zhongkai, Zhou Nengneng, Zhu Chengjian
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , Shanghai 200032, China.
出版信息
Org Lett. 2016 Mar 4;18(5):1143-5. doi: 10.1021/acs.orglett.6b00257. Epub 2016 Feb 24.
A K2S2O8/Cu(OAc)2-mediated oxidative C-H/P-H cross-coupling of aldehyde hydrazones with diphenylphosphine oxide for the direct preparation of functionalized α-iminophosphine oxides is reported. The reaction shows good functional group tolerance and proceeds smoothly under mild conditions. This strategic protocol for C-P bond formation is facilitated by a net oxidative aminyl radical-polar crossover process.
报道了一种K2S2O8/Cu(OAc)2介导的醛腙与二苯基氧化膦的氧化C-H/P-H交叉偶联反应，用于直接制备功能化的α-亚氨基氧化膦。该反应具有良好的官能团耐受性，在温和条件下顺利进行。这种形成C-P键的策略性方法是通过净氧化氨基自由基-极性交叉过程实现的。
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