Yamane H, Katoh N, Tani N, Iwase N, Takahashi S
Folia Psychiatr Neurol Jpn. 1977;31(2):167-71. doi: 10.1111/j.1440-1819.1977.tb02717.x.
A case of Gilles de la Tourette's syndrome with alcoholism and migraine is described. Multiple motor tics and coprolalia were suppressed by the treatment with haloperidol. The concentration of HVA and 5-HIAA in the cerebrospinal fluid were measured and increment of HVA concentrations was outstanding while his symptoms were aggravated. This might be evidence for hyperactivity of dopaminergic neurons involved in manifest symptomatology of this syndrome.
本文描述了一例患有妥瑞氏综合征、酒精中毒和偏头痛的病例。通过使用氟哌啶醇治疗，多重运动性抽动和秽语症得到了抑制。对脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度进行了测量，在其症状加重时，HVA浓度显著升高。这可能是该综合征明显症状所涉及的多巴胺能神经元活动亢进的证据。
