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镥-前列腺特异性膜抗原 617 放射性配体治疗后恢复激素反应的转移性前列腺癌。

Metastatic Prostate Cancer With Restored Hormone-Response After Radioligand Therapy With 177Lu-PSMA-617.

机构信息

From the *Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany; and †Private Office for Urology, Bonn, Germany.

出版信息

Clin Nucl Med. 2016 Jul;41(7):572-3. doi: 10.1097/RLU.0000000000001200.

DOI:10.1097/RLU.0000000000001200
PMID:26909718
Abstract

An 80-year-old patient with castrate-resistant prostate cancer presented to our department for PSMA imaging because of a rising prostate-specific antigen (PSA) level. The tumor was diagnosed in 2004. GnRh analog was the only treatment the patient received. Two cycles of Lu-PSMA-617 were performed with a 2-month interval in between. Ten months after finishing with 2 cycles of Lu-PSMA therapy, we noticed a continuous falling PSA level and a decreasing tumor spread in the PET/CT imaging just under the hormone therapy.

摘要

一位 80 岁的去势抵抗性前列腺癌患者因前列腺特异性抗原(PSA)水平升高到我科进行 PSMA 成像。该肿瘤于 2004 年诊断。患者仅接受了促性腺激素释放激素类似物治疗。两次 Lu-PSMA-617 治疗,两次治疗之间间隔 2 个月。完成 2 个周期的 Lu-PSMA 治疗后 10 个月,我们注意到在激素治疗下的 PET/CT 成像中 PSA 水平持续下降,肿瘤扩散减少。

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