植物烷氧基苯到天然烷氧基萘类似物的简便合成。
Facile Synthesis of Natural Alkoxynaphthalene Analogues from Plant Alkoxybenzenes.
机构信息
N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
Institute of Developmental Biology, RAS , Vavilov Street, 26, 119334, Moscow, Russian Federation.
出版信息
J Nat Prod. 2016 Apr 22;79(4):923-8. doi: 10.1021/acs.jnatprod.5b01007. Epub 2016 Feb 24.
Analogues of the bioactive natural alkoxynaphthalene pycnanthulignene D were synthesized by an efficient method. The starting plant allylalkoxybenzenes (1) are easily available from the plant essential oils of sassafras, dill, and parsley. The target 1-arylalkoxynaphthalenes (5) exhibited antiproliferative activity in a phenotypic sea urchin embryo assay.
通过一种有效的方法合成了生物活性天然烷氧基萘吡喃素 D 的类似物。起始植物烯丙基烷氧基苯（1）可从黄樟、莳萝和欧芹的植物精油中轻易获得。目标 1-芳基烷氧基萘（5）在表型海胆胚胎测定中表现出抗增殖活性。
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