Morizawa Yosuke, Miyake Makito, Shimada Keiji, Hori Shunta, Tatsumi Yoshihiro, Nakai Yasushi, Anai Satoshi, Tanaka Nobumichi, Konishi Noboru, Fujimoto Kiyohide
Department of Urology, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan.
Department of Pathology, Nara Medical University, Nara, Japan.
World J Surg Oncol. 2016 Feb 24;14(1):43. doi: 10.1186/s12957-016-0810-z.
Because retroperitoneal soft tissue sarcomas (RPS) are extremely rare, there is a significant lack of clinicopathologic information to optimize the treatment strategy. The aim of this study was to evaluate the prognostic factors in RPS, with particular focus on the Ki-67 labeling index (LI).
We included the data from a total of 23 patients who received treatment for primary RPS at a single center. The variables analyzed in this study included tumor size, histological type, malignancy grade, necrosis, mitosis, and Ki-67 LI. Kaplan-Meier and Cox proportional regression analyses of overall survival (OS) were performed to identify significant prognostic variables.
Of the 23 patients who underwent surgical resection, 9 (39%) underwent simple resection of the tumor and 14 (61%) extended resection including the adjacent organs. In the univariate analysis, a simple tumor resection and a high Ki-67 LI were associated with shorter OS. The multivariate analysis revealed that simple tumor resection and a high Ki-67 LI were independent negative prognostic factors for OS.
Our results suggested that combined resection of RPS and its adjacent organs improved OS. Pathologically, a high Ki-67 LI was significantly associated with negative prognosis.
由于腹膜后软组织肉瘤（RPS）极为罕见，严重缺乏优化治疗策略所需的临床病理信息。本研究的目的是评估RPS的预后因素，尤其关注Ki-67标记指数（LI）。
我们纳入了在单一中心接受原发性RPS治疗的23例患者的数据。本研究分析的变量包括肿瘤大小、组织学类型、恶性程度、坏死、有丝分裂和Ki-67 LI。进行Kaplan-Meier和Cox比例回归分析总生存期（OS），以确定显著的预后变量。
在接受手术切除的23例患者中，9例（39%）进行了肿瘤单纯切除，14例（61%）进行了包括相邻器官的扩大切除。单因素分析中，肿瘤单纯切除和高Ki-67 LI与较短的OS相关。多因素分析显示，肿瘤单纯切除和高Ki-67 LI是OS的独立阴性预后因素。
我们的结果表明，RPS及其相邻器官的联合切除可改善OS。病理上，高Ki-67 LI与不良预后显著相关。
