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In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery.

作者信息

Bührer Christoph

机构信息

Department of Neonatology, Charité University Medical Center Berlin, Berlin, Germany.

出版信息

Evid Based Med. 2016 Jun;21(3):93. doi: 10.1136/ebmed-2016-110400. Epub 2016 Feb 24.

DOI:10.1136/ebmed-2016-110400
PMID:26912573
Abstract
摘要

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In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery.在新生儿中，口服或直肠给予对乙酰氨基酚无法减轻操作疼痛，而静脉注射对乙酰氨基酚可减少大手术后的吗啡用量。
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[Opioids or paracetamol for postoperative analgesia in newborns and small children?].[阿片类药物还是对乙酰氨基酚用于新生儿和小儿术后镇痛？]
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The addition of tramadol to the standard of i.v. acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo-controlled trial.在静脉注射对乙酰氨基酚和吗啡输注的标准方案中添加曲马多用于新生儿术后镇痛并无临床益处：一项随机安慰剂对照试验。
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The addition of tramadol to a standard i.v. acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy?在新生儿标准静脉注射对乙酰氨基酚/吗啡镇痛方案中添加曲马多：是有意为之还是仅仅是联合用药？
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引用本文的文献

1
A Critical Review on the Relevance of Paracetamol for Procedural Pain Management in Neonates.对扑热息痛在新生儿程序性疼痛管理中的相关性的批判性综述。
Front Pediatr. 2020 Mar 18;8:89. doi: 10.3389/fped.2020.00089. eCollection 2020.