Wang A, An X, Xia V W
Departments of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Departments of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Transplant Proc. 2016 Jan-Feb;48(1):120-2. doi: 10.1016/j.transproceed.2016.01.004.
Although female patients are associated with several complications after liver transplantation (OLT), its role in short-term postoperative outcomes is not known. The aims of this study were to investigate the relationship between female gender and ventilation time and hospital stay after OLT.
After receiving institutional review board approval, we studied adult patients who underwent OLT at our center between 2004 and 2013. Female and male recipients were compared by using Student t and χ(2) tests. Risk factors were confirmed in multivariate logistic models.
Of 1476 patients, 490 were female. Compared with male counterparts, female recipients had more severe disease and comorbidities. Intraoperatively, the 2 groups were similar except for blood transfusion. Postoperatively, female recipients required significantly longer ventilation time (median, 3 days [interquartile range (IQR), 2-5], vs median, 2 [IQR, 1-5]; P = .009) and duration of hospital stay (median, 23 [IQR, 15-46] vs median, 18 [IQR, 12-34]; P < .001) compared with male recipients. Female gender was an independent risk factor for prolonged posttransplant ventilation time (≥3 days; odds ratio [OR], 1.65; P < .001) and hospital stay (≥19 days; OR, 1.48; P = .003).
Female gender of the recipient is associated with significantly longer ventilation time and hospital stay after OLT and the management should be tailored to the unique characteristics and susceptibility to postoperative complications in female patients.
尽管肝移植（OLT）术后女性患者会出现多种并发症，但其在术后短期结局中的作用尚不清楚。本研究旨在探讨女性性别与OLT术后通气时间和住院时间之间的关系。
在获得机构审查委员会批准后，我们研究了2004年至2013年期间在本中心接受OLT的成年患者。通过学生t检验和χ²检验对女性和男性受者进行比较。在多因素逻辑模型中确定危险因素。
1476例患者中，490例为女性。与男性受者相比，女性受者的疾病和合并症更严重。术中，除输血外，两组相似。术后，与男性受者相比，女性受者需要显著更长的通气时间（中位数为3天[四分位间距（IQR），2 - 5]，而中位数为2[IQR，1 - 5]；P = 0.009）和住院时间（中位数为23[IQR，15 - 46]，而中位数为18[IQR，12 - 34]；P < 0.001）。女性性别是移植后通气时间延长（≥3天；比值比[OR]，1.65；P < 0.001）和住院时间延长（≥19天；OR，1.48；P = 0.003）的独立危险因素。
受者为女性与OLT术后显著更长的通气时间和住院时间相关，管理应根据女性患者的独特特征和术后并发症易感性进行调整。
