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Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-(14)C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins.

作者信息

Shirvani Gholamhossein, Shockravi Abbas, Amini Mohsen, Saemian Nader

机构信息

Nuclear Science Research School, Nuclear Science and Technology Research Institute, End of North Karegar Ave, 14395-836, Tehran, Iran.

Faculty of Chemistry, Kharazmi University (formerly Tarbiat Moallem University), 49 Mofetteh Avenue, 15719-14911, Tehran, Iran.

出版信息

J Labelled Comp Radiopharm. 2016 Apr;59(4):153-6. doi: 10.1002/jlcr.3382. Epub 2016 Feb 24.

DOI:10.1002/jlcr.3382
PMID:26916231
Abstract

4,5-Diarylimidazoles labeled with carbon-14 in the 5-position of the imidazole ring were prepared as a part of three-step sequence from 2-hydroxy-1-(4-(methylthio)phenyl)-2-phenyl[1-(14) C]ethanone as a key synthetic intermediate which has been synthesized from potassium [(14) C]cyanide.

摘要

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