Krueger J M, Johannsen L
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
J Rheumatol Suppl. 1989 Nov;19:52-7.
Sleep deprivation, infection and administration of muramyl peptides or certain other immune response modifiers all alter sleep. Sleep, temperature and hematologic effects observed after bacterial infection are also elicited after administration of isolated bacterial cell walls. Macrophages have the capability to digest bacterial peptidoglycan and in the process produce pyrogenic and somnogenic substances of low molecular weight. Activated macrophages also produce cytokines and some of these, e.g., interleukin-1 (IL-1), are somnogenic. Our results emphasize the close connection of the infection process, fever and sleep. Muramyl peptides and/or IL-1 may also be involved in daily regulation of sleep.
睡眠剥夺、感染以及给予胞壁酰肽或某些其他免疫反应调节剂均会改变睡眠。细菌感染后观察到的睡眠、体温和血液学效应，在给予分离的细菌细胞壁后也会出现。巨噬细胞有能力消化细菌肽聚糖，并在此过程中产生低分子量的致热和致眠物质。活化的巨噬细胞还会产生细胞因子，其中一些，如白细胞介素-1（IL-1），具有致眠作用。我们的结果强调了感染过程、发热与睡眠之间的紧密联系。胞壁酰肽和/或IL-1也可能参与睡眠的日常调节。
