Kumar Sathish
Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, 632004, India.
Indian J Pediatr. 2016 Apr;83(4):322-7. doi: 10.1007/s12098-016-2060-z. Epub 2016 Feb 26.
Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition characterized by fever, lymphadenopathy, arthritis, rash and serositis. In sJIA, systemic inflammation has been associated with dysregulation of the innate immune system, suggesting that it is an autoinflammatory disorder. IL-1 and IL-6 play a major role in the pathogenesis of sJIA and treatment with IL-1 and IL-6 inhibitors has shown to be highly effective. Recent data suggests that early cytokine blockage might abrogate chronic, destructive, therapy resistant arthritis phase, reflecting a potential "window of opportunity" in the care of children with sJIA.
全身型幼年特发性关节炎（sJIA）是一种炎症性疾病，其特征为发热、淋巴结病、关节炎、皮疹和浆膜炎。在sJIA中，全身炎症与先天性免疫系统失调有关，提示这是一种自身炎症性疾病。白细胞介素-1（IL-1）和白细胞介素-6（IL-6）在sJIA的发病机制中起主要作用，使用IL-1和IL-6抑制剂进行治疗已显示出高效性。最近的数据表明，早期细胞因子阻断可能消除慢性、破坏性、抗治疗性关节炎阶段，这反映了在sJIA患儿护理中存在潜在的“机会窗口”。
