Dipartimento di Pediatria, Università di Genova, Pediatria II e Reumatologia, Istituto G Gaslini, Genova, Italy.
Autoimmun Rev. 2012 Nov;12(1):56-9. doi: 10.1016/j.autrev.2012.07.022. Epub 2012 Aug 2.
Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in the pathogenesis is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long term prognosis.
全身性幼年特发性关节炎（sJIA）与所有其他类型的 JIA 明显不同。有几项观察结果表明，sJIA 在发病机制上与所有其他类型的 JIA 不同，并且具有明显的自身炎症成分。两种促炎细胞因子白细胞介素 6 和白细胞介素 1 在发病机制中起主要作用。这两种细胞因子的特异性抑制不仅将改变疾病的治疗方法，而且可能改变其长期预后。
