Bohlen Martin O, Chen Lewis L
Program in Neuroscience, University of Mississippi Medical Center, Jackson, Mississippi.
Departments of Otolaryngology and Communicative Sciences, Neurobiology and Anatomical Sciences, Neurology, and Ophthalmology, University of Mississippi Medical Center, Jackson, Mississippi.
J AAPOS. 2016 Feb;20(1):12-8. doi: 10.1016/j.jaapos.2015.10.019.
Extraocular proprioception has been shown to participate in spatial perception and binocular alignment. Yet the physiological approaches used to study this sensory signal are limited because proprioceptive signaling takes place at the same time as visuomotor signaling. It is critical to dissociate this sensory signal from other visuomotor events that accompany eye movements.
We present a novel noninvasive and quantifiable method for probing extraocular proprioception independent of other visuomotor processing by attaching a rare-earth magnet to a real-time model eye and placing an electromagnet <20 mm from the eye. An electromagnet can increase or decrease angular displacements and velocities of the model eye.
Electromagnetic activation rapidly affected (<2 ms) the rotation kinematics of the eye, which were correlated linearly with both the current supply and the distance of the electromagnet relative to the eye.
This method circumvented the constraints of conventional physiological manipulation of extraocular proprioception, such as manually or mechanically tugging on the eye ball. It can be applied to produce the discrepancy between the intended and the executed eye movements, so that proprioceptive reafference signals are dissociated from corollary motor discharges and other visuomotor events.
已证明眼外本体感觉参与空间感知和双眼对齐。然而，用于研究这种感觉信号的生理学方法有限，因为本体感觉信号与视觉运动信号同时发生。将这种感觉信号与伴随眼球运动的其他视觉运动事件区分开来至关重要。
我们提出了一种新颖的非侵入性且可量化的方法，通过将稀土磁体附着到实时模型眼上，并将电磁铁放置在距眼睛<20毫米处，来探测独立于其他视觉运动处理的眼外本体感觉。电磁铁可以增加或减少模型眼的角位移和速度。
电磁激活迅速影响（<2毫秒）眼睛的旋转运动学，其与电流供应以及电磁铁相对于眼睛的距离呈线性相关。
该方法规避了传统眼外本体感觉生理操作的限制，如手动或机械牵拉眼球。它可用于产生预期和执行的眼球运动之间的差异，从而使本体感觉再传入信号与伴随运动放电和其他视觉运动事件分离。
