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特应性皮炎的认识与管理进展

Advances in understanding and managing atopic dermatitis.

作者信息

Barton Michael, Sidbury Robert

机构信息

University of Washington School of Medicine, Seattle, WA, 98195, USA.

Department of Pediatric Dermatology, Seattle Children's Hospital, Seattle, WA, 98105, USA.

出版信息

F1000Res. 2015 Nov 19;4. doi: 10.12688/f1000research.6972.1. eCollection 2015.

DOI:10.12688/f1000research.6972.1
PMID:26918129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4753999/
Abstract

Atopic dermatitis is a chronic, pruritic skin disease characterized by an improperly functioning skin barrier and immune dysregulation. We review proposed atopic dermatitis pathomechanisms, emphasizing how these impact current perspectives on natural history, role of allergic sensitization, and future therapeutic targets.

摘要

特应性皮炎是一种慢性瘙痒性皮肤病，其特征为皮肤屏障功能异常和免疫失调。我们综述了特应性皮炎的发病机制，重点阐述了这些机制如何影响当前对自然病程、过敏致敏作用以及未来治疗靶点的认识。

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1
Advances in understanding and managing atopic dermatitis.特应性皮炎的认识与管理进展
F1000Res. 2015 Nov 19;4. doi: 10.12688/f1000research.6972.1. eCollection 2015.
2
Future perspectives in the treatment of atopic dermatitis.特应性皮炎治疗的未来展望。
J Dermatol. 2009 Jul;36(7):367-76. doi: 10.1111/j.1346-8138.2009.00662.x.
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Skin barrier and immune dysregulation in atopic dermatitis: an evolving story with important clinical implications.特应性皮炎中的皮肤屏障与免疫失调：一个不断发展且具有重要临床意义的故事。
J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):371-9; quiz 380-1. doi: 10.1016/j.jaip.2014.03.006. Epub 2014 Apr 25.
4
Atopic Dermatitis in Animals and People: An Update and Comparative Review.动物与人类的特应性皮炎：最新进展与比较综述
Vet Sci. 2017 Jul 26;4(3):37. doi: 10.3390/vetsci4030037.
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Emerging small-molecule compounds for treatment of atopic dermatitis: a review.用于治疗特应性皮炎的新型小分子化合物：综述
Expert Opin Ther Pat. 2016;26(1):21-34. doi: 10.1517/13543776.2016.1101451. Epub 2015 Oct 15.
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The multiple factors affecting the association between atopic dermatitis and contact sensitization.影响特应性皮炎与接触致敏相关性的多种因素。
Allergy. 2014 Jan;69(1):28-36. doi: 10.1111/all.12358. Epub 2013 Dec 26.
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Atopic dermatitis and skin allergies - update and outlook.特应性皮炎和皮肤过敏——更新与展望。
Allergy. 2013 Dec;68(12):1509-19. doi: 10.1111/all.12324. Epub 2013 Nov 26.
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Immunologic aspects of atopic dermatitis.特应性皮炎的免疫学方面。
Acta Dermatovenerol Croat. 2009;17(3):226-34.
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Skin barrier function in atopic dermatitis.特应性皮炎中的皮肤屏障功能。
Curr Opin Pediatr. 2007 Feb;19(1):89-93. doi: 10.1097/MOP.0b013e328012315a.
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Molecular basis of atopic dermatitis.特应性皮炎的分子基础。
Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):382-6. doi: 10.1097/ACI.0b013e3282a643c3.

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Angelica Yinzi alleviates 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis by inhibiting activation of NLRP3 inflammasome and down-regulating the MAPKs/NF-kB signaling pathway.当归饮子通过抑制NLRP3炎性小体的激活和下调MAPKs/NF-κB信号通路减轻1-氯-2,4-二硝基苯诱导的特应性皮炎。
Saudi Pharm J. 2022 Oct;30(10):1426-1434. doi: 10.1016/j.jsps.2022.07.003. Epub 2022 Jul 19.
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Effect of NGR1 on the Atopic Dermatitis Model and its Mechanisms.NGR1对特应性皮炎模型的影响及其机制。
Open Med (Wars). 2019 Nov 10;14:847-853. doi: 10.1515/med-2019-0099. eCollection 2019.
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IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration.IL-4 驱动的转录因子 FoxQ1 由特应性皮炎中的单核细胞表达，并刺激单核细胞迁移。
Sci Rep. 2017 Dec 4;7(1):16847. doi: 10.1038/s41598-017-17307-z.
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Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice.富氢水可改善NC/Nga小鼠特应性皮炎样皮损的严重程度，并减少白细胞介素-1β、白细胞介素-33和肥大细胞浸润。
Saudi Med J. 2017 Sep;38(9):928-933. doi: 10.15537/smj.2017.9.20807.
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Evolving Concepts in Atopic Dermatitis.特应性皮炎的演变概念
Curr Allergy Asthma Rep. 2017 Jul;17(7):42. doi: 10.1007/s11882-017-0710-5.

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Off-Label Uses of Omalizumab.奥马珠单抗的非标签用途。
Clin Rev Allergy Immunol. 2016 Feb;50(1):84-96. doi: 10.1007/s12016-015-8490-y.
2
Randomized trial of peanut consumption in infants at risk for peanut allergy.对有花生过敏风险婴儿食用花生的随机试验。
N Engl J Med. 2015 Feb 26;372(9):803-13. doi: 10.1056/NEJMoa1414850. Epub 2015 Feb 23.
3
Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis.局部TrkA激酶抑制剂CT327是治疗银屑病瘙痒的一种有效新型疗法：实验研究结果以及CT327在银屑病患者2b期临床试验中的疗效与安全性
Acta Derm Venereol. 2015 May;95(5):542-8. doi: 10.2340/00015555-2047.
4
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis.度普利尤单抗可改善中重度特应性皮炎患者的皮肤分子特征。
J Allergy Clin Immunol. 2014 Dec;134(6):1293-1300. doi: 10.1016/j.jaci.2014.10.013.
5
Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy.特应性皮炎会增强接触灰尘中花生抗原对花生致敏以及可能引发花生过敏的影响。
J Allergy Clin Immunol. 2015 Jan;135(1):164-70. doi: 10.1016/j.jaci.2014.10.007. Epub 2014 Nov 18.
6
Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial.奥马珠单抗对重度难治性特应性皮炎患儿的免疫效应：一项随机、安慰剂对照临床试验。
Pediatrics. 2014 Nov;134 Suppl 3:S160. doi: 10.1542/peds.2014-1817UU.
7
Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children.随机对照试验维生素 D 补充剂治疗儿童冬季相关特应性皮炎。
J Allergy Clin Immunol. 2014 Oct;134(4):831-835.e1. doi: 10.1016/j.jaci.2014.08.002.
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Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention.从出生起使用润肤剂增强皮肤屏障可有效预防特应性皮炎。
J Allergy Clin Immunol. 2014 Oct;134(4):818-23. doi: 10.1016/j.jaci.2014.08.005.
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Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches.解读特应性皮炎的复杂性：治疗方法的范式转变
J Allergy Clin Immunol. 2014 Oct;134(4):769-79. doi: 10.1016/j.jaci.2014.08.008.
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