Hsu Benjumin, Cumming Robert G, Hirani Vasant, Blyth Fiona M, Naganathan Vasi, Le Couteur David G, Seibel Markus J, Waite Louise M, Handelsman David J
ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
J Clin Endocrinol Metab. 2016 Apr;101(4):1836-46. doi: 10.1210/jc.2015-3810. Epub 2016 Feb 26.
Although androgen status decreases with aging in unselected men, the contemporaneous relationship over time between circulating hormones and androgen-sensitive outcomes has not been reported.
To investigate the temporal relationships between age-specific androgen status and muscle (mass, strength), hemoglobin, and prostate-specific antigen (PSA).
DESIGN, SETTING AND PARTICIPANTS: Men aged 70 years and older from the Concord Health and Ageing in Men Project study were assessed at baseline (2005–2007; n = 1705) and at 2-year (n = 1367) and 5-year follow-up (n = 958).
At all assessments, serum T, dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry, and serum SHBG, LH, and FSH were measured by immunoassay together with calculation of free T (cFT). Muscle mass, strength of upper (hand grip) and lower (walking speed) limbs, hemoglobin, and prostate size (serum PSA) were measured.
Serum hormones showed longitudinal, within-man decreases in serum T (−2.6%/y), DHT (−2.6%/y), E1 (−3.2%/y), and cFT (−2.8%/y) but increases in serum E2 (2.6%/y), SHBG (1.3%/y), LH (1.9%/y), and FSH (1.8%/y). Significant positive correlation was observed between changes in serum T with muscle mass, strength, and hemoglobin but not with PSA across the three time-points. Changes in serum DHT, cFT, and E1 had significant correlation with muscle mass, strength, and hemoglobin, but not with PSA.
These extended observational data are consistent with the impact of reduced androgen status on some somatic features of male aging. However, they do not exclude reverse causality or independent effects of aging on both androgen status and androgen-sensitive outcomes.
尽管在未经过挑选的男性中，雄激素水平会随着年龄增长而下降，但循环激素与雄激素敏感结局之间随时间变化的同期关系尚未见报道。
研究特定年龄的雄激素水平与肌肉（质量、力量）、血红蛋白及前列腺特异性抗原（PSA）之间的时间关系。
设计、地点和参与者：对来自康科德男性健康与老龄化项目研究的70岁及以上男性在基线期（2005 - 2007年；n = 1705）、2年随访期（n = 1367）和5年随访期（n = 958）进行评估。
在所有评估中，采用液相色谱 - 串联质谱法测定血清睾酮（T）、双氢睾酮（DHT）、雌二醇（E2）和雌酮（E1），采用免疫分析法测定血清性激素结合球蛋白（SHBG）、促黄体生成素（LH）和促卵泡生成素（FSH），并计算游离睾酮（cFT）。测量肌肉质量、上肢（握力）和下肢（步行速度）力量、血红蛋白以及前列腺大小（血清PSA）。
血清激素显示，男性血清T（−2.6%/年）、DHT（−2.6%/年）、E1（−3.2%/年）和cFT（−2.8%/年）呈纵向下降，而血清E2（2.6%/年）、SHBG（1.3%/年）、LH（1.9%/年）和FSH（1.8%/年）呈上升。在三个时间点上，血清T的变化与肌肉质量、力量和血红蛋白之间存在显著正相关，但与PSA无相关性。血清DHT、cFT和E1的变化与肌肉质量、力量和血红蛋白存在显著相关性，但与PSA无相关性。
这些扩展的观察数据与雄激素水平降低对男性衰老某些躯体特征的影响一致。然而，它们并不排除反向因果关系或衰老对雄激素水平和雄激素敏感结局的独立影响。
