Su Xuan, Li Zhaoqu, He Caiyun, Chen Weichao, Fu Xiaoyan, Yang Ankui
Department of Head and Neck, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Oncotarget. 2016 Mar 29;7(13):16716-30. doi: 10.18632/oncotarget.7574.
RET/PTC rearrangements have been identified as a specific genetic event in papillary thyroid cancer (PTC). We conducted this meta-analysis to identify an enriched population who were more likely to occur RET/PTC fusion genes.
All relevant studies in the PubMed, Web of Science, and Embase databases were searched up to June 2015. The studies found were screened according to our inclusion and exclusion criteria. All analyses were performed using STATA software.
Eventually, 38 eligible studies comprising 2395 participants were included. Overall analysis indicated that radiation exposure contributed to increased RET/PTC risk (OR = 2.82; 95%CI: 1.38-5.78, P = 0.005). Stratified analysis according to RET/PTC subtype and geographical area showed that this association was restricted to the RET/PTC3 subtype (OR = 8.30, 95%CI: 4.32-15.96, P < 0.001) in the Western population. In addition, age < 18 years, i.e., young age, was associated with higher prevalence of RET/PTC3 (OR = 2.03, 95%CI: 1.14-3.62, P = 0.017), especially in the radiation-exposure subpopulation (OR = 2.35, 95%CI: 1.01-5.49, P = 0.048). The association between female gender and RET/PTC1 risk was more significant in the PTC patients without radiation exposure (OR = 1.69, 95%CI: 1.04-2.74, P = 0.034).
Both radiation exposure and young age are associated with increased risk of RET/PTC3 and that female gender is associated with higher prevalence of RET/PTC1 in the subpopulation without radiation exposure. The RET/PTC status in combination with radiation exposure, age, and sex should be considered in the differential diagnosis of suspicious PTC.
RET/PTC重排已被确定为甲状腺乳头状癌（PTC）中的一种特定基因事件。我们进行了这项荟萃分析，以确定更有可能出现RET/PTC融合基因的富集人群。
检索了截至2015年6月在PubMed、科学网和Embase数据库中的所有相关研究。根据我们的纳入和排除标准对找到的研究进行筛选。所有分析均使用STATA软件进行。
最终，纳入了38项符合条件的研究，共2395名参与者。总体分析表明，辐射暴露导致RET/PTC风险增加（OR = 2.82；95%CI：1.38 - 5.78，P = 0.005）。根据RET/PTC亚型和地理区域进行的分层分析表明，这种关联仅限于西方人群中的RET/PTC3亚型（OR = 8.30，95%CI：4.32 - 15.96，P < 0.001）。此外，年龄<18岁，即年轻，与RET/PTC3的较高患病率相关（OR = 2.03，95%CI：1.14 - 3.62，P = 0.017），尤其是在辐射暴露亚组中（OR = 2.35，95%CI：1.01 - 5.49，P = 0.048）。在无辐射暴露的PTC患者中，女性与RET/PTC1风险之间的关联更为显著（OR = 1.69，95%CI：1.04 - 2.74，P = 0.034）。
辐射暴露和年轻均与RET/PTC3风险增加相关，而女性在无辐射暴露亚组中与RET/PTC1的较高患病率相关。在可疑PTC的鉴别诊断中应考虑RET/PTC状态与辐射暴露、年龄和性别的结合。
