Kaiser Daniel, Veiros Luís F, Maulide Nuno
Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal.
Chemistry. 2016 Mar 24;22(14):4727-32. doi: 10.1002/chem.201600432. Epub 2016 Feb 25.
The Brønsted acid-mediated reaction of unactivated alkynes with aryl sulfoxides leads to simultaneous hydration and intermolecular C-C bond formation. This solvent- and metal-free transformation directly delivers α-arylated carbonyl compounds as the products of a formal hydrative arylation in an atom-economical manner. The products bear useful synthetic handles for further functionalization.
布朗斯特酸介导的未活化炔烃与芳基亚砜的反应可同时实现水合作用和分子间碳-碳键的形成。这种无溶剂、无金属的转化反应以原子经济的方式直接生成α-芳基羰基化合物，作为形式上的水合芳基化反应的产物。这些产物带有用于进一步官能化的有用合成基团。
