Yaghi Shadi, Elkind Mitchell S V
Department of Neurology, Division of Stroke and Cerebrovascular Disease, The Warren Alpert Medical School of Brown University, 593 Eddy St. APC 530, Providence, RI, 02903, USA.
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Curr Treat Options Cardiovasc Med. 2016 Apr;18(4):27. doi: 10.1007/s11936-016-0448-8.
Statins are a group of lipid-lowering agents that are competitive inhibitors of the enzyme 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase that have been used to reduce cholesterol levels and prevent cardiovascular events. Statins have been also shown to reduce the risk of stroke. In this review, we cover the role of statins in cerebrovascular disease through lipid-lowering mechanisms and other "pleiotropic" effects that provide protection against cerebrovascular events and potentially contribute to improve functional outcome after stroke.
他汀类药物是一类降脂药物，它们是3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶的竞争性抑制剂，已被用于降低胆固醇水平和预防心血管事件。他汀类药物也已被证明可降低中风风险。在本综述中，我们探讨了他汀类药物在脑血管疾病中的作用，其作用机制包括降脂作用以及其他“多效性”效应，这些效应可预防脑血管事件，并可能有助于改善中风后的功能结局。
