高价碘诱导的氧化偶联反应（新型无金属偶联反应的进展及其在天然产物合成中的应用）
Hypervalent Iodine-Induced Oxidative Couplings (New Metal-Free Coupling Advances and Their Applications in Natural Product Syntheses).
作者信息
Dohi Toshifumi, Kita Yasuyuki
机构信息
College of Pharmaceutical Science, Ritsumeikan University, 1-1-1 Nojihigasshi, Kusatsu, Shiga, 525-8577, Japan.
Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigasshi, Kusatsu, Shiga, 525-8577, Japan.
出版信息
Top Curr Chem. 2016;373:1-23. doi: 10.1007/128_2016_667.
Recently, hypervalent iodine reagents have been extensively used in organic synthesis. A variety of reactions available for natural product syntheses have been developed using phenyliodine(III) diacetate (PIDA), phenyliodine(III) bis(trifluoroacetate) (PIFA), and other iodine(III) and (V) reagents. These reactions are expected to have applications in pharmaceutical and agrochemical processes because of their safety, mild reaction conditions, and high yields of pure products. Under such considerations, this chapter focuses on the oxidative coupling reactions of hypervalent iodine reagents found in total syntheses of biologically active natural products and their related compounds.
近年来，高价碘试剂已在有机合成中得到广泛应用。利用二醋酸碘苯（PIDA）、双（三氟乙酸）碘苯（PIFA）以及其他碘（III）和碘（V）试剂，已开发出多种可用于天然产物合成的反应。由于这些反应具有安全性、温和的反应条件以及高纯度产物收率，有望在制药和农用化学品工艺中得到应用。基于这些考虑，本章重点介绍在生物活性天然产物及其相关化合物的全合成中发现的高价碘试剂的氧化偶联反应。
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