Wang Tao, Conrad Kenneth A, van Brunt Kate, Rees Tina M
Lilly Diabetes, Eli Lilly and Company, Indianapolis, IN, USA.
Delivery Device Human Factors, Eli Lilly and Company, Indianapolis, IN, USA.
J Diabetes Sci Technol. 2016 Jun 28;10(4):923-31. doi: 10.1177/1932296816633232. Print 2016 Jul.
This study compared patient preference for Humalog® KwikPen™ 200 units/mL (insulin lispro; hereafter, IL 200 pen; Eli Lilly and Company, Indianapolis, IN) versus the Humalog KwikPen 100 units/mL (insulin lispro; hereafter, IL 100 pen; Eli Lilly and Company, Indianapolis, IN) in patients with diabetes requiring >20 units of mealtime insulin and diabetes caregivers. This study also determined which attributes had the greatest influence on pen preference selection.
In this 2-period, crossover, simulated-use study, 106 participants were randomized to 1 of 8 sequences that varied the pen order (IL 100 pen or IL 200 pen) and dosing order (15 units = low dose or 50 units = high dose) for a total of 4 simulated injections. Participants then completed a self-administered questionnaire to select their overall preference between the 2 pens and then rated the importance of 11 pen attributes in contributing to their overall preference.
Of the 90 participants expressing an overall preference, significantly more preferred the IL 200 pen to the IL 100 pen (IL 200 pen: 80 respondents; IL 100 pen: 10 respondents; 95% confidence interval [0.81, 0.94], P < .0001). The total amount of insulin in the pen, the ease in pressing the injection button, and the amount of fluid injected were key attributes influencing IL 200 pen preference.
Based on these key attributes, the IL 200 pen was significantly preferred over the IL 100 pen by patients with diabetes who require >20 daily mealtime insulin units or diabetes caregivers and may improve the injection experience for these patients.
本研究比较了需要超过20单位餐时胰岛素的糖尿病患者及糖尿病护理人员对优泌乐200单位/毫升笔芯（赖脯胰岛素；以下简称IL 200笔芯；礼来公司，印第安纳波利斯，印第安纳州）和优泌乐100单位/毫升笔芯（赖脯胰岛素；以下简称IL 100笔芯；礼来公司，印第安纳波利斯，印第安纳州）的偏好。本研究还确定了哪些属性对笔芯偏好选择影响最大。
在这项为期2个阶段的交叉模拟使用研究中，106名参与者被随机分配到8种序列中的1种，这些序列改变了笔芯顺序（IL 100笔芯或IL 200笔芯）和给药顺序（15单位=低剂量或50单位=高剂量），共进行4次模拟注射。参与者随后完成一份自我管理问卷，以选择他们对两种笔芯的总体偏好，然后对11种笔芯属性对其总体偏好的重要性进行评分。
在90名表达总体偏好的参与者中，明显更多的人更喜欢IL 200笔芯而非IL 100笔芯（IL 200笔芯：80名受访者；IL 100笔芯：10名受访者；95%置信区间[0.81, 0.94]，P <.0001）。笔芯中的胰岛素总量、按下注射按钮的难易程度以及注射的液体量是影响对IL 200笔芯偏好的关键属性。
基于这些关键属性，需要每日超过20单位餐时胰岛素的糖尿病患者或糖尿病护理人员明显更喜欢IL 200笔芯而非IL 100笔芯，这可能会改善这些患者注射体验。
