Guo Yongjian, Zhang Ying, Huang Jingjun, Chen Xiuzheng, Huang Wensou, Shan Hong, Zhu Kangshun
Department of Radiology, 600 Tianhe Road, Guangzhou, Guangdong 510630, China; Department of Interventional Radiology Institute, Sun Yat-sen University, Guangzhou, Guangdong, China.
Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.
J Vasc Interv Radiol. 2016 Apr;27(4):487-95. doi: 10.1016/j.jvir.2016.01.002. Epub 2016 Feb 24.
To retrospectively evaluate safety and efficacy of conventional transarterial chemoembolization with ethiodized oil (Lipiodol) combined with CT-guided radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) adjacent to the hepatic hilum.
Between January 2007 and December 2010, conventional transarterial chemoembolization combined with CT-guided RF ablation was performed in 40 patients with HCC adjacent to the hepatic hilum within Milan criteria (group A). Major complications, complete tumor ablation rate, local tumor progression rate, and overall survival were compared with 107 patients with HCC nonadjacent to the hepatic hilum (group B) treated by conventional transarterial chemoembolization combined with CT-guided RF ablation during the same period.
Major complications included one case of large hepatic artery-portal vein fistula in group A (2.5%; 1/40) and one case of acute portal vein thrombosis, left heart failure, and tumor seeding in group B (2.8%; 3/107); the difference was not significant between the two groups (P = 1.000). There were no significant differences between the two groups in complete tumor ablation rate (80.0% vs 86.0%; P = .374), local tumor progression rates (1-year, 12.5% vs 14.1%; 2-year, 28.2% vs 24.2%; 3-year, 32.0% vs 27.6%; P = .723), and overall survival (1-year, 92.3% vs 91.8%; 3-year, 79.1% vs 79.3%; 5-year, 59.5% vs 58.4%; P = .555).
Conventional transarterial chemoembolization combined with CT-guided RF ablation was safe and effective in selected patients with HCC adjacent to the hepatic hilum within Milan criteria.
回顾性评估常规经动脉化疗栓塞联合乙碘油（碘油）与CT引导下射频（RF）消融治疗肝门部肝细胞癌（HCC）的安全性和有效性。
2007年1月至2010年12月期间，对40例符合米兰标准的肝门部HCC患者进行了常规经动脉化疗栓塞联合CT引导下RF消融（A组）。将主要并发症、肿瘤完全消融率、局部肿瘤进展率和总生存率与同期接受常规经动脉化疗栓塞联合CT引导下RF消融的107例非肝门部HCC患者（B组）进行比较。
主要并发症包括A组1例大肝动脉-门静脉瘘（2.5%；1/40）和B组1例急性门静脉血栓形成、左心衰竭和肿瘤播散（2.8%；3/107）；两组之间差异无统计学意义（P = 1.000）。两组在肿瘤完全消融率（80.0%对86.0%；P = 0.374）、局部肿瘤进展率（1年，12.5%对14.1%；2年，28.2%对24.2%；3年，32.0%对27.6%；P = 0.723）和总生存率（1年，92.3%对91.8%；3年，79.1%对
79.3%；5年，59.5%对58.4%；P = 0.555）方面均无显著差异。
对于符合米兰标准的部分肝门部HCC患者，常规经动脉化疗栓塞联合CT引导下RF消融是安全有效的。
