Zhong Li-Ting, Wang Hui, Liang Huan-Qing, Su Meng-Ru, Liu Cheng-Dong, Wu De-Hua
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):151-6.
To investigate the value of serum globulin levels before treatment in predicting the prognosis of patients with nasopharyngeal carcinoma (NPC).
A total of 127 patients with non-disseminated NPC were recruited between January, 2009 and December, 2013 at Nanfang Hospital. The pretreatment serum globulin levels were analyzed with the receiver-operating characteristic (ROC) curve analysis to select the cut-off point for low and high pretreatment serum globulin levels. Kaplan-Meier and multivariable analyses were used to evaluate the predictive value of serum globulin levels.
The ROC curve analysis determined 30.05 g/L as the optimal cut-off value for pretreatment serum globulin level, which was significantly associated with gender (P=0.024) and N stage (P=0.016). Kaplan-Meier analysis showed that a high pretreatment serum globulin level (>30.05 g/L) significantly predicted poor progression-free survival (P=0.019), overall survival (P=0.034) and distant metastasis-free survival (P=0.049); multivariate analysis identified pretreatment serum globulin level as an independent prognostic factor for progression-free survival (HR=2.344, P=0.031).
Pretreatment serum globulin level may serve as a valuable marker to predict the prognosis of patients with NPC.
探讨治疗前血清球蛋白水平对鼻咽癌（NPC）患者预后的预测价值。
2009年1月至2013年12月期间，南方医院共招募了127例未发生转移的NPC患者。采用受试者工作特征（ROC）曲线分析对治疗前血清球蛋白水平进行分析，以选择治疗前血清球蛋白水平高低的分界点。采用Kaplan-Meier法和多变量分析来评估血清球蛋白水平的预测价值。
ROC曲线分析确定治疗前血清球蛋白水平的最佳分界值为30.05 g/L，该值与性别（P = 0.024）和N分期（P = 0.016）显著相关。Kaplan-Meier分析显示，治疗前血清球蛋白水平高（>30.05 g/L）显著预示无进展生存期差（P = 0.019）、总生存期差（P = 0.034）和无远处转移生存期差（P = 0.049）；多变量分析确定治疗前血清球蛋白水平是无进展生存期的独立预后因素（HR = 2.344，P = 0.031）。
治疗前血清球蛋白水平可作为预测NPC患者预后的有价值标志物。
