类风湿关节炎合并大颗粒淋巴细胞白血病——利妥昔单抗治疗成功
Rheumatoid arthritis and associated large granular lymphocytic leukemia--successful treatment with rituximab.
作者信息
Raposo A, Cerqueira M, Costa J, Sousa Neves J, Teixeira F, Afonso C
出版信息
Acta Reumatol Port. 2015 Oct-Dec;40(4):384-7.
PMID:26922203
Abstract
Large granular lymphocytic (LGL) leukemia is an uncommon, usually indolent, lymphoproliferative disorder strongly associated with various autoimmune diseases. The authors report a case of a 67-year-old woman with a long-standing rheumatoid arthritis, who developed neutropenia and associated recurrent infections, diagnosed with LGL leukemia. We describe the treatment approach and the response to an anti-TNF and the rituximab.
摘要
大颗粒淋巴细胞（LGL）白血病是一种罕见的、通常进展缓慢的淋巴增殖性疾病，与多种自身免疫性疾病密切相关。作者报告了一例67岁患有长期类风湿性关节炎的女性病例，该患者出现中性粒细胞减少症并伴有反复感染，被诊断为LGL白血病。我们描述了其治疗方法以及对抗肿瘤坏死因子（TNF）和利妥昔单抗的反应。
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