Internal Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA
Department of Rheumatology, Georgetown University School of Medicine, Washington, District of Columbia, USA.
BMJ Case Rep. 2024 Aug 30;17(8):e260470. doi: 10.1136/bcr-2024-260470.
T-cell large granular lymphocytic (T-LGL) leukaemia is frequently associated with an autoimmune phenomenon; approximately one-third of patients have rheumatoid arthritis (RA). Intriguingly, one-third of patients with rheumatoid arthritis exhibit clonal T-cell patterns. Here, we present a patient with RA undergoing evaluation for neutropenia and splenomegaly who was later diagnosed with T-LGL leukaemia.
T 细胞大颗粒淋巴细胞（T-LGL）白血病常与自身免疫现象有关；约三分之一的患者患有类风湿关节炎（RA）。有趣的是，三分之一的类风湿关节炎患者表现出克隆性 T 细胞模式。在这里，我们介绍了一位患有 RA 的患者，该患者因中性粒细胞减少和脾肿大接受评估，随后被诊断为 T-LGL 白血病。
