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漏斗胸的微创修复:手术结果、生活质量及再次手术的预测因素

Minimally Invasive Repairs of Pectus Excavatum: Surgical Outcomes, Quality of Life, and Predictors of Reoperation.

作者信息

Gibreel Waleed, Zendejas Benjamin, Joyce Daniel, Moir Christopher R, Zarroug Abdalla E

机构信息

Department of Surgery, Mayo Clinic, Rochester, MN.

Department of Surgery, Mayo Clinic, Rochester, MN.

出版信息

J Am Coll Surg. 2016 Mar;222(3):245-52. doi: 10.1016/j.jamcollsurg.2015.11.020. Epub 2015 Nov 26.

Abstract

BACKGROUND

We sought to examine our institutional experience (1998 to 2014) with minimally invasive repairs of pectus excavatum (MIRPE).

STUDY DESIGN

We conducted a retrospective review and a mailed survey (quality of life assessment). Associations with reoperation due to bar migration and recurrence after bar removal were evaluated with logistic regression.

RESULTS

Three hundred and thirteen patients (79% male) underwent MIRPE at a mean ± SD age of 15 ± 3 years. Bar migration requiring reoperation occurred in 16 (5%) patients (median 26 days, interquartile range 15 to 70 days from repair). Wire fixation (hazard ratio [HR] = 3.16; p = 0.014) and bar stabilizer (HR = 4.57; p = 0.002) use were associated with increased risk of reoperation, and bilateral pericostal suture fixation (HR = 0.15; p < 0.001) and thoracoscopic assistance (78%, HR = 0.23; p < 0.001) were associated with decreased risks. Reoperations rates varied (6% to 26%) during the first 50 cases of each surgeon (n = 6), falling to ≤2% afterward. Of the 101 (32%) patients who have had their bars removed electively, 10 (10%) have required reoperation for recurrence. Patients with a recurrence after bar removal were younger (14.1 ± 3.9 years vs 18.4 ± 3.7 years; p = 0.007) and had their bars removed earlier (2.4 ± 1.2 years vs 3.8 ± 2.1 years; p = 0.036). Of survey respondents (n = 145 [47%]), most (99%) were either very happy (n = 79) or mostly happy (n = 63) with their outcomes.

CONCLUSIONS

Although excellent outcomes after MIRPE can be achieved, our results highlight identified strategies that are associated with decreased risk of reoperation (eg, use of bilateral pericostal suture fixation, surgeon experience, and thoracoscopic guidance). Our results also suggest that elective bar removal should be delayed until the patient is at least 18 years old and has had the bar in for at least 4 years.

摘要

背景

我们试图研究我院(1998年至2014年)微创漏斗胸修复术(MIRPE)的经验。

研究设计

我们进行了一项回顾性研究和一项邮寄调查(生活质量评估)。采用逻辑回归评估与因钢板移位和取出钢板后复发而再次手术的相关性。

结果

313例患者(79%为男性)接受了MIRPE手术,平均年龄±标准差为15±3岁。16例(5%)患者因钢板移位需要再次手术(中位数为26天,从修复到再次手术的四分位间距为15至70天)。使用钢丝固定(风险比[HR]=3.16;p=0.014)和钢板稳定器(HR=4.57;p=0.002)与再次手术风险增加相关,而双侧肋周缝合固定(HR=0.15;p<0.001)和胸腔镜辅助(78%,HR=0.23;p<0.001)与风险降低相关。每位外科医生的前50例手术(n=6)中再次手术率各不相同(6%至26%),之后降至≤2%。在101例(32%)已择期取出钢板的患者中,10例(10%)因复发需要再次手术。取出钢板后复发的患者更年轻(14.1±3.9岁对18.4±3.7岁;p=0.007),且钢板取出时间更早(2.4±1.2年对3.8±2.1年;p=0.036)。在调查对象(n=145[47%])中,大多数(99%)对手术结果非常满意(n=79)或基本满意(n=63)。

结论

虽然MIRPE术后可取得优异的效果,但我们的研究结果突出了一些已确定的与降低再次手术风险相关的策略(如使用双侧肋周缝合固定、外科医生经验和胸腔镜引导)。我们的研究结果还表明,择期取出钢板应推迟至患者至少18岁且钢板置入至少4年之后。

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