Möllhoff T, Mulier J P, Müller E, van Aken H, Lauwers P
Departement Anesthesiologie, Universitätskliniken, Katholieke Universiteit Leuven, Belgien.
Z Kardiol. 1989 Nov;78(11):732-7.
20 patients who developed arterial hypertension following coronary artery bypass grafting were randomly treated with either sodium nitroprusside (SNP) or urapidil. Both drugs led to a significant decrease in blood pressure. A significant tachycardia was noted only in the SNP-group. A decrease in peripheral and pulmonary vascular resistance was seen in both groups. Following application of SNP, alveolarterial oxygen difference and venous admixture increased significantly, whereas PaO2 showed a significant decrease. Three patients had to be taken out of the SNP group because of an increase of venous admixture. Alveoloarterial oxygen difference and venous admixture showed no significant changes following application of urapidil.
20例冠状动脉旁路移植术后发生动脉高血压的患者被随机分为硝普钠（SNP）组或乌拉地尔组进行治疗。两种药物均使血压显著降低。仅在SNP组观察到显著的心动过速。两组外周和肺血管阻力均降低。应用SNP后，肺泡动脉氧分压差和静脉血掺杂显著增加，而动脉血氧分压（PaO2）显著降低。3例患者因静脉血掺杂增加而退出SNP组。应用乌拉地尔后，肺泡动脉氧分压差和静脉血掺杂无显著变化。
