Falkenhagen D, Thomaneck U, Brown G S, Werner H, Klinkmann H
Klinik für Innere Medizin, Wilhelm-Pieck-Universität, Rostock, DDR.
Z Urol Nephrol. 1989 Oct;82(10):541-50.
The release of biological active factors from blood cells, e.g. interleukin 1, is of importance with regard to the bioavailability testing of membranes for extracorporeal blood purification. The data from an in vitro system of cytokine release may show a connection between complement activation and cytokine (interleukin) release of membranes. In contrast the results of the generation rate of beta 2-microglobulin did show no definite reference to complement activation or cytokine release. Further time-dependent investigations of the generation rate beta 2-microglobulin are necessary.
血细胞释放生物活性因子，如白细胞介素1，对于体外血液净化膜的生物利用度测试具有重要意义。细胞因子释放体外系统的数据可能显示补体激活与膜的细胞因子（白细胞介素）释放之间存在联系。相比之下，β2-微球蛋白生成率的结果并未明确显示与补体激活或细胞因子释放有关。有必要对β2-微球蛋白生成率进行进一步的时间依赖性研究。
