Wüstenberg P W, Dörp E, Schumann L, Adam U, Adam H, Falkenhagen D, Klinkmann H
Abteilung Pathophysiologie, Bereiches Medizin der Wilhelm-Pieck-Universität Rostock.
Z Urol Nephrol. 1989 Oct;82(10):551-66.
On the view of 1989 older and modern developments to a bioartificial implantable hybrid kidney are presented. To the realization proof of the implantable hemofilter-intestine-hybrid kidney the routes were described in an experimental rat model to the plasmakinetic simulation of the urea and sodium level as a marker of the hybrid kidney functions. The results of the bioartificial hemofilter-intestine-hybrid kidney development are presented, but significant detail problems must be solved, especially the hemofilter biocompatibility problem.
本文介绍了1989年以来生物人工可植入混合肾脏的旧有及现代进展。为实现可植入血液滤过器-肠道-混合肾脏的可行性验证,在实验大鼠模型中描述了对尿素和钠水平进行血浆动力学模拟的途径,以此作为混合肾脏功能的标志物。文中呈现了生物人工血液滤过器-肠道-混合肾脏的研发成果,但仍有一些重大细节问题有待解决,尤其是血液滤过器的生物相容性问题。