Wang Jing, Liu Shenquan, Wang Hongchu, Ju Niansheng, Zeng Yanjun
1 School of Mathematics, South China University of Technology , Guangzhou 510640, China.
Neurol Res. 2015;37(12):1074-81. doi: 10.1080/01616412.2015.1110304.
As the principal cell of the striatum, medium spiny neurons (MSNs) are closely associated with various motor dysfunctional diseases. In this paper, we describe an electric compartment model constructed in NEURON with a realistic morphology. Based on a 554-compartment computational model, we researched the influence of external current stimuli, different ions conductance, and the removal of partial dendrites on the physiological properties of the MSN. The main results are the following: (1) in the case of external current stimuli, various firing patterns appear in the MSN and the model produces a clear period-adding bifurcation phenomenon; (2) the effect of distinct types of ion channels vary and significant differences in discharge rhythm exist even among ion channels of the same type; (3) the closer the removed dendrite was to the soma, the larger the impact this had on the discharge pattern of the MSN.
作为纹状体的主要细胞，中等棘状神经元（MSNs）与各种运动功能障碍性疾病密切相关。在本文中，我们描述了一个在NEURON中构建的具有真实形态的电隔室模型。基于一个554隔室的计算模型，我们研究了外部电流刺激、不同离子电导以及去除部分树突对MSN生理特性的影响。主要结果如下：（1）在外部电流刺激的情况下，MSN中出现各种放电模式，且该模型产生明显的加周期分岔现象；（2）不同类型离子通道的作用各不相同，即使是同一类型的离子通道，其放电节律也存在显著差异；（3）去除的树突离胞体越近，对MSN放电模式的影响就越大。
