Temporal variation in the distribution of type-1 human astrovirus lineages in a settled population over 14 years.
作者信息
De Grazia Simona, Bonura Floriana, Bányai Krisztián, Gellért Ákos, Marineo Sandra, Martella Vito, Giammanco Giovanni M
机构信息
Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, via del Vespro 133, 90127, Palermo, Italy.
Veterinary Medical Research Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
出版信息
Arch Virol. 2016 Jun;161(6):1633-7. doi: 10.1007/s00705-016-2798-7. Epub 2016 Feb 29.
Human astroviruses (HAstVs) are important enteric pathogens that are genetically and antigenically heterogeneous and can be classified into eight sero/genotypes (HAstV-1 to -8) and different lineages within each HAstV type. This study describes the genetic diversity of HAstVs circulating in southern Italy over 14 years. Molecular analysis of HAstV-1 strains showed that three different lineages (1a, 1b and 1d) of the predominant genotype were circulating during the study period. The study of an archival collection of HAstV strains offers a unique opportunity to evaluate the patterns of variation of HAstV infections over the years and to correlate the observed epidemiological changes to the genetic variability of HAstVs.
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