一项针对意大利儿科人群中人类星状病毒感染的全国性监测研究。
Nationwide surveillance study of human astrovirus infections in an Italian paediatric population.
机构信息
Dipartimento di Scienze per la Promozione della Salute 'G. D'Alessandro', Università di Palermo, Palermo, Italy.
Dipartimento di Sanità Pubblica e Zootecnia, Università Aldo Moro di Bari, Bari, Italy.
出版信息
Epidemiol Infect. 2013 Mar;141(3):524-8. doi: 10.1017/S0950268812000945. Epub 2012 May 17.
Abstract
The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008-2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT-PCR amplification of a portion at the 5'-end of ORF2 allowed the detection of HAstVs in 3·95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.
摘要
该研究调查了 2008 年至 2009 年在意大利因肠胃炎住院的儿童中检测到的人类星状病毒 (HAstV) 的遗传多样性。在帕尔马（意大利北部）、巴里（意大利南部）和巴勒莫（西西里岛）共采集了 1321 份粪便样本，并对 HAstV 的存在进行了筛查。通过 RT-PCR 扩增 ORF2 5'端的一部分，在 3.95%的患者中检测到了 HAstV。研究期间发现了四种不同的基因型（HAstV-1、HAstV-2、HAstV-4 和 HAstV-5），其中 HAstV-1 是主要类型。有趣的是，在 2009 年，研究人员在帕尔马发现了一种新的谱系，被提议为 HAstV-2d。研究 HAstV 的遗传变异性对于了解这些病毒的流行病学趋势和进化将非常重要。
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