Takada Ayato
Hokkaido University Research Center for Zoonosis Control.
Uirusu. 2015;65(1):61-70. doi: 10.2222/jsv.65.61.
Filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever in humans and nonhuman primates. No effective prophylaxis or treatment for filovirus diseases is yet commercially available. The recent outbreak of Ebola virus disease in West Africa has accelerated efforts to develop anti-Ebola virus prophylaxis and treatment, and unapproved drugs were indeed used for the treatment of patients during the outbreak. This article reviews previous researches and the latest topics on vaccine and therapy for Ebola virus disease.
丝状病毒(埃博拉病毒和马尔堡病毒)可导致人类和非人类灵长类动物患上严重出血热。目前尚无针对丝状病毒疾病的有效预防或治疗方法可供商业使用。最近在西非爆发的埃博拉病毒病加速了抗埃博拉病毒预防和治疗药物的研发,在疫情期间确实使用了未经批准的药物来治疗患者。本文回顾了此前关于埃博拉病毒病疫苗和治疗方法的研究及最新进展。