Pitts Elizabeth G, Taylor Jane R, Gourley Shannon L
Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States; Interdepartmental Neuroscience Program, Department of Psychology, Yale University, New Haven, CT, United States.
Neurobiol Dis. 2016 Jul;91:326-35. doi: 10.1016/j.nbd.2016.02.021. Epub 2016 Feb 26.
Brain-derived neurotrophic factor (BDNF) affects synaptic plasticity and neural structure and plays key roles in learning and memory processes. Recent evidence also points to important, yet complex, roles for BDNF in rodent models of cocaine abuse and addiction. Here we examine the role of prefrontal cortical (PFC) BDNF in reward-related decision making and behavioral sensitivity to, and responding for, cocaine. We focus on BDNF within the medial and orbital PFC, its regulation by cocaine during early postnatal development and in adulthood, and how BDNF in turn influences responding for drug reinforcement, including in reinstatement models. When relevant, we draw comparisons and contrasts with experiments using natural (food) reinforcers. We also summarize findings supporting, or refuting, the possibility that BDNF in the medial and orbital PFC regulate the development and maintenance of stimulus-response habits. Further investigation could assist in the development of novel treatment approaches for cocaine use disorders.
脑源性神经营养因子（BDNF）影响突触可塑性和神经结构，并在学习和记忆过程中发挥关键作用。最近的证据还表明，BDNF在可卡因滥用和成瘾的啮齿动物模型中起着重要但复杂的作用。在这里，我们研究前额叶皮质（PFC）BDNF在与奖励相关的决策以及对可卡因的行为敏感性和反应中的作用。我们关注内侧和眶额PFC内的BDNF、可卡因在出生后早期发育和成年期对其的调节，以及BDNF如何反过来影响对药物强化的反应，包括在复吸模型中的反应。在相关情况下，我们将使用天然（食物）强化物的实验进行比较和对比。我们还总结了支持或反驳内侧和眶额PFC中的BDNF调节刺激-反应习惯的发展和维持这一可能性的研究结果。进一步的研究可能有助于开发针对可卡因使用障碍的新型治疗方法。
