Uchida A, Esa A, Uemura T, Kurita T, Okuyama A
Department of Urology, Kinki University School of Medicine.
Hinyokika Kiyo. 1989 Oct;35(10):1781-5.
A case of mixed gonadal dysgenesis with anaplastic seminoma is herein reported. A 38-years-old man was admitted to our hospital with the chief complaint of a painful mass, 19.0 cm in long diameter in his lower abdomen. At 11, 13 and 14 years old he had the history of treatment for an ambiguous external genitalia and defect of both scrotal contents. In the concrete, laparotomy, chordectomy and urethroplasty were performed at those times and the laparotomy revealed a right immature abdominal testis and Müllerian structures. Laboratory examination revealed elevated levels of serum lactic dehydrogenase and HCG. The karyotype from the cultured lymphocyte was that of a normal male. Because the histological finding of biopsied abdominal tumor was shown to be an anaplastic seminoma, firstly two courses of chemotherapy using cisplatin vinblastine and bleomycin were induced, and that after an extensive resection for the tumor and Müllerian structure including some portions of surrounding tissue was performed. We reviewed 40 cases of mixed gonadal dysgenesis reported previously in the Japanese literature and 8 cases of that with a gonadal tumor.
本文报告一例合并间变性精原细胞瘤的混合型性腺发育不全病例。一名38岁男性因下腹部有一长径19.0 cm的疼痛性肿块为主诉入院。他在11岁、13岁和14岁时曾因外生殖器模糊和双侧阴囊内容物缺如接受治疗。具体而言，当时进行了剖腹手术、精索切除术和尿道成形术，剖腹手术发现右侧未成熟的腹腔内睾丸和苗勒管结构。实验室检查显示血清乳酸脱氢酶和人绒毛膜促性腺激素水平升高。培养淋巴细胞的核型为正常男性核型。由于活检腹部肿瘤的组织学检查结果显示为间变性精原细胞瘤，首先采用顺铂、长春碱和博来霉素进行了两个疗程的化疗，之后对肿瘤和苗勒管结构包括周围部分组织进行了广泛切除。我们回顾了日本文献中先前报道的40例混合型性腺发育不全病例以及8例合并性腺肿瘤的病例。
