Lafaye C, Feillel V, Dauplat J, De Latour M
Ann Radiol (Paris). 1989;32(5):400-9.
Three hundred and eighty nine preoperative localizations were performed in the senology department of the Centre Jean Perrin in 349 patients presenting with an isolated radiological image with no associated clinical signs (discovered on routine or selective screening examinations). The most frequent anomaly detected was the presence of areas of microcalcifications, sometimes associated with a high-density lesion or more rarely an opacity. Systematic enlargements allowed refinement of the surgical indications and reduced the number of tumourectomies performed for benign lesions. The histological results consisted of 41% of neoplastic and borderline lesions with a predominance of in situ or microinvasive forms without lymph node involvement. The mean age at the time of diagnosis was 40 years, i.e. ten years younger that the mean age of cancer diagnosis. The percentage of subclinical cancers discovered in this way, increased by screening and improvement in surgical techniques, has been further increased by enlargements which have improved the precision of surgical indications. Stereotactic localization allows the surgeon and pathologist to more accurately define the lesion while preserving the appearance of the breast.
让·佩兰中心乳腺科对349例患者进行了389次术前定位，这些患者的影像学检查结果孤立，无相关临床体征（在常规或选择性筛查检查中发现）。检测到的最常见异常是微钙化区域的存在，有时与高密度病变相关，或更罕见地与不透明影相关。系统性扩大检查有助于完善手术指征，并减少了因良性病变而进行的肿瘤切除术数量。组织学结果显示，41%为肿瘤性和交界性病变，以原位或微浸润形式为主，无淋巴结受累。诊断时的平均年龄为40岁，比癌症诊断的平均年龄小10岁。通过筛查和手术技术的改进发现的亚临床癌症百分比，因扩大检查提高了手术指征的精确性而进一步增加。立体定向定位使外科医生和病理学家能够在保留乳房外观的同时更准确地界定病变。
