Davis Benjamin P, Rothenberg Marc E
Division of Immunology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242; email:
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; email:
Annu Rev Pathol. 2016 May 23;11:365-93. doi: 10.1146/annurev-pathol-012615-044241. Epub 2016 Feb 24.
Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.
嗜酸性粒细胞性食管炎(EoE)是一种最近才被认识的食管炎症性疾病,其临床症状源于食管功能障碍。EoE的病因目前正在阐明,食物超敏反应正成为疾病发病机制的核心基石。在此,我们全面介绍了目前对该疾病的临床、病理和分子方面的认识,重点关注疾病机制。