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极早产儿白质病变与全身运动评估及婴儿运动能力测试表现之间的关系。

Relationship between white matter pathology and performance on the General Movement Assessment and the Test of Infant Motor Performance in very preterm infants.

作者信息

Peyton Colleen, Yang Edward, Kocherginsky Masha, Adde Lars, Fjørtoft Toril, Støen Ragnhild, Bos Arend F, Einspieler Christa, Schreiber Michael D, Msall Michael E

机构信息

Department of Therapy Services, University of Chicago Medicine, 5841 S. Maryland Ave, Chicago, IL 60637, USA.

Department of Pediatrics, University of Chicago Medicine, Comer Children's Hospital, Sections of Neonatology, Developmental Pediatrics, 5841 S. Maryland Ave, Chicago, IL 60637, USA; Kennedy Research Center on Intellectual and Neurodevelopmental Disabilities, 5841 S. Maryland Ave, Chicago, IL 60637, USA.

出版信息

Early Hum Dev. 2016 Apr;95:23-7. doi: 10.1016/j.earlhumdev.2016.01.017. Epub 2016 Feb 27.

DOI:10.1016/j.earlhumdev.2016.01.017
PMID:26925933
Abstract

BACKGROUND

Cerebral Magnetic Resonance Imaging, the General Movement Assessment, and the Test of Infant Motor Performance are all tools that can predict neurodevelopmental outcome in preterm infants. However, how these tests relate to each other is unclear.

AIMS

To examine the relationship between cerebral Magnetic Resonance Imaging measured at term age, and the General Movement Assessment and Test of Infant Motor Performance measured at 10-15 weeks post-term age.

STUDY DESIGN

Prospectively collected data in a sample of very preterm infants.

SUBJECTS

Fifty-three infants (23 female, 30 male) with a median gestational age of 28 weeks (range: 23-30 weeks) and a median birth weight of 1000 g (range: 515-1465 g).

OUTCOME MEASURES

Test of Infant Motor Performance, General Movement Assessment.

RESULTS

Infants with abnormal white matter were significantly more likely to have both abnormal general movements (p=0.01) and abnormal Test of Infant Motor Performance scores (p=0.001). Infants with abnormal general movements were significantly more likely to have lower Test of Infant Motor Performance Scores (p=0.01).

CONCLUSIONS

Abnormal white matter is related to motor deviations as measured by the General Movement Assessment and the Test of Infant Motor Performance as early as 3 months post-term age in a cohort of preterm infants.

摘要

背景

脑磁共振成像、全身运动评估和婴儿运动能力测试都是可预测早产儿神经发育结局的工具。然而,这些测试之间的相互关系尚不清楚。

目的

研究足月时测量的脑磁共振成像与足月后10 - 15周测量的全身运动评估和婴儿运动能力测试之间的关系。

研究设计

前瞻性收集极早产儿样本的数据。

研究对象

53例婴儿(23例女性,30例男性),中位胎龄28周(范围:23 - 30周),中位出生体重1000 g(范围:515 - 1465 g)。

观察指标

婴儿运动能力测试、全身运动评估。

结果

白质异常的婴儿出现全身运动异常(p = 0.01)和婴儿运动能力测试分数异常(p = 0.001)的可能性显著更高。全身运动异常的婴儿婴儿运动能力测试分数更低的可能性显著更高(p = 0.01)。

结论

在一组早产儿中,早在足月后3个月时,白质异常就与通过全身运动评估和婴儿运动能力测试所测量的运动偏差有关。

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