Döring C, Müller M, Hagenmuller F, Ajdacic-Gross V, Haker H, Kawohl W, Rössler W, Heekeren K
The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Eur Psychiatry. 2016 Apr;34:9-16. doi: 10.1016/j.eurpsy.2016.01.001. Epub 2016 Feb 27.
Deficits of mismatch negativity (MMN) in schizophrenia and individuals at risk for psychosis have been replicated many times. Several studies have also demonstrated the occurrence of subclinical psychotic symptoms within the general population. However, none has yet investigated MMN in individuals from the general population who report subclinical psychotic symptoms.
The MMN to duration-, frequency-, and intensity deviants was recorded in 217 nonclinical individuals classified into a control group (n=72) and three subclinical groups: paranoid (n=44), psychotic (n=51), and mixed paranoid-psychotic (n=50). Amplitudes of MMN at frontocentral electrodes were referenced to average. Based on a three-source model of MMN generation, we conducted an MMN source analysis and compared the amplitudes of surface electrodes and sources among groups.
We found no significant differences in MMN amplitudes of surface electrodes. However, significant differences in MMN generation among the four groups were revealed at the frontal source for duration-deviant stimuli (P=0.01). We also detected a trend-level difference (P=0.05) in MMN activity among those groups for frequency deviants at the frontal source.
Individuals from the general population who report psychotic symptoms are a heterogeneous group. However, alterations exist in their frontal MMN activity. This increased activity might be an indicator of more sensitive perception regarding changes in the environment for individuals with subclinical psychotic symptoms.
精神分裂症患者及有精神病风险个体的失匹配负波（MMN）缺失已被多次重复验证。多项研究还表明普通人群中存在亚临床精神病性症状。然而，尚无研究调查过报告有亚临床精神病性症状的普通人群个体的MMN情况。
记录了217名非临床个体对时长、频率和强度偏差刺激的MMN，这些个体被分为一个对照组（n = 72）和三个亚临床组：偏执型（n = 44）、精神病型（n = 51）和偏执 - 精神病混合型（n = 50）。额中央电极处的MMN波幅以平均值为参照。基于MMN产生的三源模型，我们进行了MMN源分析，并比较了各组表面电极和源的波幅。
我们发现表面电极的MMN波幅无显著差异。然而，在时长偏差刺激的额叶源处，四组之间MMN产生存在显著差异（P = 0.01）。我们还在额叶源处的频率偏差刺激中检测到这些组之间MMN活动存在趋势水平差异（P = 0.05）。
报告有精神病性症状的普通人群个体是一个异质性群体。然而，他们的额叶MMN活动存在改变。这种增强的活动可能是亚临床精神病性症状个体对环境变化感知更敏感的一个指标。
