父母药物滥用与子女注意力缺陷多动障碍之间的跨代传递。
Cross-generational transmission from drug abuse in parents to attention-deficit/hyperactivity disorder in children.
作者信息
Kendler K S, Ohlsson H, Sundquist K, Sundquist J
机构信息
Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Center for Primary Health Care Research,Lund University,Malmö,Sweden.
出版信息
Psychol Med. 2016 Apr;46(6):1301-9. doi: 10.1017/S0033291715002846.
Abstract
BACKGROUND
Attention-deficit/hyperactivity disorder (ADHD) predisposes to drug abuse (DA) and twin studies suggest shared genetic effects. We here seek to determine, using adoption and adoption-like samples, the magnitude of the cross-generational transmission from DA in parents to ADHD in their children and clarify the degree to which this arises from genetic v. rearing effects.
METHOD
We ascertained ADHD and DA from multiple Swedish registries. Statistical analysis was performed by Cox and path models.
RESULTS
Risk for ADHD was significantly and similarly increased in the offspring of biological mothers and fathers with DA who did v. did not rear their offspring. Risk for ADHD was not elevated in the offspring of adoptive or step-parents with DA.
CONCLUSIONS
Cross-generational transmission was observed from DA in parents to ADHD in their children. An analysis of adoptive and adoptive-like parent-offspring relationships suggested that this transmission results from genetic and not from rearing effects.
摘要
背景
注意力缺陷多动障碍（ADHD）易导致药物滥用（DA），双生子研究表明存在共同的遗传效应。我们在此试图通过收养及类似收养的样本，确定父母的药物滥用对其子女患注意力缺陷多动障碍的跨代传递程度，并阐明这种传递在多大程度上源于遗传与养育效应。
方法
我们从多个瑞典登记处确定了注意力缺陷多动障碍和药物滥用情况。采用Cox模型和路径模型进行统计分析。
结果
亲生父母患有药物滥用且抚养或未抚养其子女的情况下，其子女患注意力缺陷多动障碍的风险均显著且相似地增加。养父母或继父母患有药物滥用时，其子女患注意力缺陷多动障碍的风险并未升高。
结论
观察到父母的药物滥用会跨代传递给其子女的注意力缺陷多动障碍。对收养及类似收养的亲子关系分析表明，这种传递是由遗传而非养育效应导致的。
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