Xie Peizhong, Guo Lei, Xu Lanlan, Loh Teck-Peng
College of Chemistry and Molecular Engineering, Nanjing Tech University, 211816, P. R. China.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Chem Asian J. 2016 May 6;11(9):1353-6. doi: 10.1002/asia.201600108. Epub 2016 Mar 29.
A novel catalytic asymmetric P-C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C-stereogenic phosphorus compounds in high yields with high regio- and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched (SP )-phosphinates through kinetic resolution.
开发了一种在次膦酸酯/氧化膦与烯丙基碳酸酯之间形成新型催化不对称P-C键的方法。该方法不仅能够以高收率、高区域选择性和非对映选择性得到多种官能化的相邻P，C-立体中心磷化合物，还能提供一种通过动力学拆分获得对映体富集的（SP）-次膦酸酯的替代策略。
