Deshayes S, Bouvier N, Chatelet V, Hurault de Ligny B, Dargère S, Bonhomme J, Béchade C
Department of Internal Medicine, CHU de Caen, Caen, France.
Department of Nephrology, CHU de Caen, Caen, France.
Transpl Infect Dis. 2016 Jun;18(3):461-465. doi: 10.1111/tid.12522. Epub 2016 Apr 7.
Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome (IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies.
隐球菌病是器官移植受者的一个主要问题。目前建议在开始抗真菌治疗后减少免疫抑制剂的用量，但偶尔可能会并发免疫重建炎症综合征（IRIS）。我们报告了一例肾移植受者的隐球菌病病例，该病例并发了严重的神经系统IRIS，尽管使用了抗肿瘤坏死因子-α单克隆抗体，但其预后仍不理想。
