玻璃体内注射酮咯酸用于治疗白内障手术后慢性黄斑囊样水肿。
Intravitreal ketorolac for the treatment of chronic cystoid macular edema after cataract surgery.
作者信息
Tsilimbaris Miltiadis K, Tsika Chrysanthi, Kymionis George D
机构信息
Department of Ophthalmology, University of Crete, Heraklion, Greece.
出版信息
Ther Clin Risk Manag. 2016 Feb 12;12:177-82. doi: 10.2147/TCRM.S97342. eCollection 2016.
PURPOSE
To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine.
METHODS
Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and OCT were performed before every injection, 1, 2, 3 weeks, and 1, 3, and 6 months after the last injection. Fluorescein angiography was performed at baseline examination, 1, 3, and 6 months after the last injection.
RESULTS
In both cases, the edema regressed and visual acuity increased. At 6 months after the last injection, the leakage was significantly reduced at the fluorescein angiography.
DISCUSSION
Both cases responded favorably to the consecutive intravitreal administration of ketorolac tromethamine. The long-lasting remission of the macular edema in these chronic cases underlines the therapeutic potential of these agents when delivered intravitreally.
目的
报告两例慢性术后黄斑囊样水肿病例，局部治疗无效，采用连续玻璃体内注射酮咯酸氨丁三醇进行治疗。
方法
给每位患者每日玻璃体内注射4次500μg/0.05mL的酮咯酸。在每次注射前、最后一次注射后1周、2周、3周以及1个月、3个月和6个月进行全面的临床检查和光学相干断层扫描（OCT）。在基线检查时、最后一次注射后1个月、3个月和6个月进行荧光素血管造影。
结果
两例患者的水肿均消退，视力提高。最后一次注射后6个月，荧光素血管造影显示渗漏明显减少。
讨论
两例患者对连续玻璃体内注射酮咯酸氨丁三醇均反应良好。这些慢性病例中黄斑水肿的长期缓解突出了这些药物玻璃体内给药时的治疗潜力。
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