疼痛管理的药物基因组学：个性化医疗的前景。
The pharmacogenomics of pain management: prospects for personalized medicine.
作者信息
Ting Sonya, Schug Stephan
机构信息
Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Anaesthesiology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia; Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, University of Western Australia Anaesthesiology Unit, Royal Perth Hospital, Perth, WA, Australia.
出版信息
J Pain Res. 2016 Feb 10;9:49-56. doi: 10.2147/JPR.S55595. eCollection 2016.
Abstract
Pain is a common symptom that can be complex to treat. Analgesic medications are the mainstay treatment, but there is wide interindividual variability in analgesic response and adverse effects. Pharmacogenomics is the study of inherited genetic traits that result in these individual responses to drugs. This narrative review will attempt to cover the current understanding of the pharmacogenomics of pain, examining common genes affecting metabolism of analgesic medications, their distribution throughout the body, and end organ effects.
摘要
疼痛是一种常见症状，其治疗可能很复杂。镇痛药是主要的治疗手段，但个体对镇痛的反应和不良反应存在很大差异。药物基因组学是研究导致个体对药物产生这些反应的遗传性状。这篇叙述性综述将试图涵盖目前对疼痛药物基因组学的理解，研究影响镇痛药代谢的常见基因、它们在全身的分布以及对终末器官的影响。
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