Huber M A, Hall E H
Ear Nose Throat J. 1989 Oct;68(10):771-5.
Various types of nutritional deficiencies can produce glossodynia and associated signs of inflammation. Changes such as swelling of the tongue, papillary atrophy, and surface ulceration are possible in most of the deficiency states. To further complicate the clinical picture, the patient commonly will suffer from multiple nutritional deficiencies [29]. Therefore, it is not advisable to diagnose a specific nutritional deficiency on clinical impression alone. To establish iron, folate, or vitamin-B12 deficiency, a hematologic screening that includes complete blood count, red-cell, serum iron, B12, and folate levels should be performed [30]. Although they are rarely required, specific tests for suspected niacin, pyridoxine, and riboflavin deficiency are available. Although glossodynia related to nutritional deficiency is statistically uncommon, it is easily curable with replacement therapy. Identification of a vitamin deficiency through early oral symptoms can forestall development of serious and irreversible systemic and neurologic damage.
多种类型的营养缺乏可导致舌痛及相关炎症体征。在大多数营养缺乏状态下，可能会出现诸如舌肿胀、乳头萎缩和表面溃疡等变化。使临床情况更为复杂的是，患者通常会患有多种营养缺乏症[29]。因此，仅根据临床印象诊断特定的营养缺乏是不可取的。为确定铁、叶酸或维生素B12缺乏，应进行包括全血细胞计数、红细胞、血清铁、B12和叶酸水平在内的血液学筛查[30]。虽然很少需要，但对于疑似烟酸、吡哆醇和核黄素缺乏有特定检测方法。虽然与营养缺乏相关的舌痛在统计学上并不常见，但通过替代疗法很容易治愈。通过早期口腔症状识别维生素缺乏可预防严重且不可逆的全身和神经损伤的发展。
