Hardy-Bayle M C, Lecrubier Y, Lancrenon S, Laine J, Allilaire J F, Des Lauriers A
Travail du Service du Pr D. Widlöcher, U 302, Hôpital de la Salpêtrière, Paris.
Encephale. 1989 Nov-Dec;15(6):523-6.
Clonidine efficacy was evaluated in 24 manic inpatients, hospitalised in a locked ward. This is a double blind and randomized study. The duration of the trial was 14 days, and the daily dose of clonidine was 0.225 mg/day during the first week, increased to 0.450 mg/day during the second week, in the case of incomplete improvement. There was a trend for a better efficacy of clonidine over placebo, but this did not reach significant, due to an important amelioration of many patients under placebo. The effects of the hospitalisation in a locked ward are discussed.
对24名被收治在封闭病房的躁狂症住院患者的可乐定疗效进行了评估。这是一项双盲随机研究。试验为期14天，若改善不完全，第一周可乐定的日剂量为0.225毫克/天，第二周增至0.450毫克/天。与安慰剂相比，可乐定有疗效更好的趋势，但由于许多接受安慰剂治疗的患者病情有显著改善，该趋势未达到显著水平。文中讨论了封闭病房住院治疗的效果。
