Balanzó J, Sainz S, Espinós J C, Such J, Segura J, Guarner C, Cussó X, Vilardell F
Escuela de Patología Digestiva, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Endoscopy. 1989 Nov;21(6):251-3. doi: 10.1055/s-2007-1012963.
A prospective randomized trial has been undertaken to compare the efficacy of two sclerosing agents, Ethanolamine oleate (Et) and Polidocanol (Pl), in the eradication of esophageal varices (EV). Fifty consecutive cirrhotic patients, 22 in the Et and 28 in the Pl group, were included. Clinical data were comparable in both groups. Eradication of the EV was achieved in 81% (18/22) in the Et group and 64.1% (18/28) in the Pl group (p = NS). There was a significant difference in the rate of rebleeding (4 episodes in 3 patients in the Et group and 18 episodes in 13 patients in the Pl group, p less than 0.05). No differences were noted in the number of other complications or mortality. Both sclerosants have proved useful in the eradication of EV, but Et was superior to Pl in the preventation of recurrent bleeding in the course of repeated endoscopic injection sclerotherapy (EIS).
已开展一项前瞻性随机试验，比较两种硬化剂油酸乙醇胺（Et）和聚多卡醇（Pl）根除食管静脉曲张（EV）的疗效。纳入了50例连续的肝硬化患者，Et组22例，Pl组28例。两组临床数据具有可比性。Et组81%（18/22）的食管静脉曲张实现根除，Pl组为64.1%（18/28）（p =无显著性差异）。再出血率存在显著差异（Et组3例患者出现4次出血事件，Pl组13例患者出现18次出血事件，p<0.05）。在其他并发症数量或死亡率方面未发现差异。两种硬化剂在根除食管静脉曲张方面均已证明有效，但在重复内镜注射硬化疗法（EIS）过程中，Et在预防复发性出血方面优于Pl。
