Ji Junfeng, Wang Qiuping, Zhang Yong, Wang Zhiyi, Shi Xu, Guan Weijie, Wu Kunmin, Xu Li, Chen Wei, Xue Fei, Jiang Manjie, Cheng You, Wang Tianyou, Zhong Nanshan
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;29(21):1864-7.
Observe the changes of small airway function in patients with rhinitis but without asthma and/or lower airway symptoms.
Between June 2008 and December 2012, we recruited 903 subjects, including 377 with allergic rhinitis (AR), 262 with non-allergic rhinitis (NAR) and 264 healthy subjects. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, pulmonary ventilation function test and bronchial challenge test.
The indices of FEV1/FVC%, MEF25pred% and MMEFpred% were lower in AR group than in the control group (P < 0.05). The indices of FEV1/FVC, MMEFpred%, MEF25pred% and MEF50pred% were also lower in NAR group than in the control group (P < 0.05). According to the FVCpred% and FEV1pred%, there were no differences between rhinitis group and the control group (P > 0.05). The positive rate of airway hyperresponsiveness(AHR) in AR group and in NAR group was 12.2%, 6.1% respectively. Indices of small airway function were all lower in the AHR group than NAHR group in rhinitis.
Compared with healthy controls, small airway function in patients with rhinitis has apparent changes, part of rhinitis patients has AHR, and is associated with small airway function changes.
观察无哮喘和/或下呼吸道症状的鼻炎患者小气道功能的变化。
2008年6月至2012年12月，我们招募了903名受试者，包括377名变应性鼻炎（AR）患者、262名非变应性鼻炎（NAR）患者和264名健康受试者。所有受试者均接受了详细的病史采集、鼻腔检查、变应原皮肤点刺试验、血常规检查、血清总免疫球蛋白E测定、肺通气功能检查和支气管激发试验。
AR组的FEV1/FVC%、MEF25pred%和MMEFpred%指标低于对照组（P<0.05）。NAR组的FEV1/FVC、MMEFpred%、MEF25pred%和MEF50pred%指标也低于对照组（P<0.05）。根据FVCpred%和FEV1pred%，鼻炎组与对照组之间无差异（P>0.05）。AR组和NAR组的气道高反应性（AHR）阳性率分别为12.2%、6.1%。鼻炎患者中AHR组的小气道功能指标均低于NAHR组。
与健康对照相比，鼻炎患者的小气道功能有明显变化，部分鼻炎患者存在AHR，且与小气道功能变化有关。
